ChemicalBook > CAS DataBase List > (3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone

(3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone

Product Name
(3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone
CAS No.
201856-53-3
Chemical Name
(3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone
Synonyms
Paclitaxel side chains;SIDE CHAINS OF PACLITAXEL--1;(3R,4S)-1-Benzoyl-3-(2-Ethoxye;1-benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone;(3R,4S)-3-(1-ethoxyethoxy)-4-phenyl-N-benzoyl-2-azetidinone;(3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone;(3R,4S)-1-benzoyl-3-(1-ethoxyethoxy)-4-phenylazetidin-2-one;(3R,4S)-1-BENZOYL-3-(2-ETHOXYETHOXYL)-4-PHENYL-2-AZETIDINONE;2-Azetidinone,1-benzoyl-3-(1-ethoxyethoxy)-4-phenyl-, (3R,4S)-;(3R,4S)-1-Benzoyl-3-(1-Ethoxyethoxy)-4-Phenyl-2-AzetidinoneCasNo.
CBNumber
CB8854814
Molecular Formula
C20H21NO4
Formula Weight
339.39
MOL File
201856-53-3.mol
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(3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone Property

Boiling point:
464.8±55.0 °C(Predicted)
Density 
1.22
storage temp. 
2-8°C
pka
-4.83±0.60(Predicted)
CAS DataBase Reference
201856-53-3(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FB148182
Product name
(3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone
Packaging
50mg
Price
$63
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB148182
Product name
(3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone
Packaging
100mg
Price
$110
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB148182
Product name
(3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone
Packaging
250mg
Price
$220
Updated
2021/12/16
AK Scientific
Product number
Q749
Product name
(3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone
Packaging
250mg
Price
$347
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB148182
Product name
(3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone
Packaging
500mg
Price
$380
Updated
2021/12/16
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(3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone Chemical Properties,Usage,Production

Uses

(3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone is an investigational intermediate chemical for Paclitaxel and Docetaxel.

Synthesis

To a solution of 2.35 g (10 mmol) of cis-3-(1-ethoxyethoxy)-4-phenylazetidin-2-one in 40 mL of THF at -78° C, was added 6.1 mL (10.07 mmol) of a 1.65M solution of n-butyllithium in hexane. The mixture was stirred for 10 min at -78° C and a solution of 1.42 g (10.1 mmol) of benzoyl chloride in 10 mL of THF was added. The mixture was stirred at -78° C for 1 h diluted with 70 mL of saturated aqueous sodium bicarbonate and extracted with three 50 mL portions of ethyl acetate. The combined ethyl acetate extracts were dried over sodium sulfate and concentrated to give 3.45 g of oil. Chromatography of the oil on silica gel eluted with ethyl acetate/hexane gave 3.22 g (95%) of (3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone as a colorless oil.

(3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone Preparation Products And Raw materials

Raw materials

Preparation Products

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(3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone Suppliers

China 65 Europe 2 Germany 1 United Kingdom 3 United States 7 Global 78
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10658
Advantage
60
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63711
Advantage
58
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View Lastest Price from (3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone manufacturers

Sinoway Industrial co., ltd.
Product
(3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone 201856-53-3
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
99% up, High Density
Supply Ability
20 tons
Release date
2021-08-12
Longyan Tianhua Biological Technology Co., Ltd
Product
(3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone 201856-53-3
Price
US $63.00/KG
Min. Order
1KG
Purity
99
Supply Ability
1000KG
Release date
2020-11-17
Career Henan Chemical Co
Product
(3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone 201856-53-3
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-13

201856-53-3, (3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinoneRelated Search:

PHENYL VALERATE 2-Ethoxyethanol Ethoxyethyne Diethoxymethyl acetate Benzoyl peroxide Benzoyl chloride Ethyl vinyl ether Ethoxyquin DIETHOXYMETHANE PHENYL RESIN Phenylacetic acid (3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone Docetaxel Cyclobutanone 2-Azetidinone Docetaxel PACLITAXEL SIDE CHAIN NO 1 Paclitaxel

  • (3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone
  • (3R,4S)-1-Benzoyl-3-(1-Ethoxyethoxy)-4-Phenyl-2-AzetidinoneCasNo.
  • (3R,4S)-1-BENZOYL-3-(2-ETHOXYETHOXYL)-4-PHENYL-2-AZETIDINONE
  • 1-benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone
  • Paclitaxel side chains
  • (3R,4S)-3-(1-ethoxyethoxy)-4-phenyl-N-benzoyl-2-azetidinone
  • 2-Azetidinone,1-benzoyl-3-(1-ethoxyethoxy)-4-phenyl-, (3R,4S)-
  • (3R,4S)-1-Benzoyl-3-(2-Ethoxye
  • DOCETAXEL SIDE CHAIN / (3R,4S)-1-BENZOYL-3-(2-ETHOXYETHOXY)-4-PHENYL-2-PHENYL-AZETIDIONE
  • (3R,4S)-1-BENZOYL-3-(2-ETHOXYETHOXYL) -4-PHENYL-2-AZETIDINONE 97%
  • SIDE CHAINS OF PACLITAXEL--1
  • (3R,4S)-1-benzoyl-3-(1-ethoxyethoxy)-4-phenylazetidin-2-one
  • Paclitaxel Side Chain (Azelidinone) 1-Benzoyl-3-(1-Ethoxyethoxy)-4-Phenyl-2-Azetidinone
  • (3R, 4S) -1-Benzoyl-3- (1-ethoxyethoxy) -4-phenyl-2-azacyclobutanone
  • 201856-53-3
  • Intermediates